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KMID : 1188320120060040452
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Gut and Liver
2012 Volume.6 No. 4 p.452 ~ p.456
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Rifaximin Plus Levofloxacin-Based Rescue Regimen for the Eradication of Helicobacter pylori
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Yun Sang-Pil
Seon Han-Gyung
Ok Chang-Soo
Yoo Kwang-Ho
Kang Min-Kyung
Kim Won-Hee
Kwon Chang-Il
Ko Kwang-Hyun
Hwang Seong-Gyu
Park Pil-Won
Hong Sung-Pyo
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Abstract
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Background/Aims:This study assessed the efficacy of a rifaximin plus levofloxacin-based rescue regimen in patients that had failed both triple and quadruple standard regimens for the eradication of Helicobacter pylori.
Methods:We treated patients for H. pylori between August 2009 and April 2011. The triple regimen consisted of combined treatment with amoxicillin, clarithromycin, and pantoprazole for 1 week. For failed cases, a quadruple regimen of tetracycline, metronidazole, bismuth dicitrate, and lansoprazole for 1 week was administered. The rescue regimen for persistently refractory cases was rifaximin 200 mg t.i.d., levofloxacin 500 mg q.d., and lansoprazole 15 mg b.i.d. for 1 week.
Results:In total, 482 patients were enrolled in this study. The eradication rates associated with the first and second regimens were 58% and 60%, respectively. Forty-seven out of 58 patients who failed with the second-line regimen received rifaximin plus levofloxacin-based third-line therapy. The eradication rate for the third regimen was 65%. The cumulative eradication rates were 58%, 85%, and 96% for each regimen, respectively.
Conclusions:A rifaximin plus levofloxacin-based regimen could be an alternative rescue therapy in patients with resistance to both triple and quadruple regimens for the eradication of H. pylori.
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KEYWORD
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Helicobacter pylori, Eradication, Rifaximin
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